Amphetamine welches discovered over 100 years ago. Since then, it has transformed from a drug that was freely available without prescription as a panacea for a broad Warenangebot of disorders into a highly restricted Controlled Drug with therapeutic applications restricted to attention deficit hyperactivity disorder (ADHD) and narcolepsy. This Bericht describes the relationship between chemical structure and pharmacology of amphetamine and its congeners.
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stimulation of striatal dopamine transmission by amphetamine: evidence from microdialysis and Fos immunohistochemistry. J Neurosci
amphetamine when taken orally make it less rewarding (pleasurable) than copyright or methamphetamine. copyright, whether snorted or smoked as ‘crack’ rein particular, enters the brain very quickly, and appears even to be concentrated in the brain relative to plasma; this explains the high rewarding potential of this drug: faster brain entry leads to a greater ‘high’.
-amphetamine is a competitive substrate for DAT rather than a classical reuptake inhibitor, these same principles apply to its pharmacological action. Thus, the rate and magnitude of neuronal dopamine release produced by amphetamine is absolutely dependent on the Satz and concentration of drug that reaches DAT sites hinein the brain (Heal et al.
Another less well-recognised factor in drug abuse is a desire of users for instant gratification. Thus, the appeal of a particular drug as a recreational substance of abuse is to a large extent determined by its ability to produce its desired effects within minutes, for example the copyright ‘rush’.
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-amphetamine makes an important contribution to its pharmacology. How lisdexamfetamine’s distinctive pharmacokinetic/pharmacodynamic profile translates into sustained efficacy as a treatment for ADHD and its reduced potential for recreational abuse is also discussed.
Different mechanisms leading to a 50% reduction in monoamine reuptake produced by a classical reuptake inhibitor versus a competitive substrate (releasing Schnüffler).
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The authors wish to thank Shire Pharmaceuticals for their more info support funding a portion of the writers’ time for the literature Nachprüfung and writing of this manuscript.